Regulation of Germline Transcription

Accurate transcriptional regulation in the germline is essential for proper development of gametes and future offspring. We are specifically interested in understanding the transcriptional programs involved in the differentiation of female germline stem cells into a mature oocytes. This includes both the transcription of factors required for the development of the oocyte itself, but also the expression of several RNAs and proteins that drive early embryonic development (maternally-deposited RNAs and proteins). We have little insight into what activates the expression of these maternal factors. In collaboration with Dr. Brian Oliver at NIDDK, we are investigating several candidate transcription factors to determine their role in the female germline and early embryo using the model system Drosophila melanogaster.